Main menu


2022 NFL Kickoff Game Odds, Spreads and Lines: Top Expert NFL Predictions for Rams vs. Bills Picks, 44-33 Rolls

The 2022 NFL regular season kicks off with a preview of a potential Super Bowl when the Los Angeles Rams host the Buffalo Bills in the 2022 NFL Kickoff Game on Thursday, Sept. 8. Cincinnati Bengals in February. Most sportsbooks list Los Angeles as a top five favorite in his 2023 Super Bowl odds, but the Bills are currently the sole favorite at 6-1. They saw his playoff run cut short last season with a crushing 42-36 overtime loss to the Kansas City Chiefs. Kickoff is at 8:20 PM ET.

Caesars Sportsbook’s latest Bills vs. Rams odds show that the Bills are the 2.5-point favourites, with 53 over-under points earned. Before finalizing the Rams vs. Bills pick, check out his NFL predictions and betting advice from SportsLine football his analyst RJ White.

White, fantasy and gambling editor at CBS Sports, constantly thrashes SportsLine’s number one NFL expert against the spread. He went 445-378-24 in his ATS picks for 2017-21, returning $2,542 to a $100 player. What’s more, he’s also 44-33 in the NFL picks involving the Rams, giving us important insight into this matchup.

White is known for winning big money at the Westgate Las Vegas Supercontest twice since 2015. Also in 2021, he made a lot of money in NFL futures, including taking Jonathan Taylor as his leader in the NFL Rush, where he went 10-1. Anyone who follows him is making huge profits.

Now, White has studied every angle of the Bills-Rams Week 1 matchup and confidently released his picks for the spread. Visit SportsLine today to see White’s picks. Here are the Bills vs. Rams NFL odds and betting lines:

  • Bills vs. Rams Point Spread: Bills -2.5
  • Bills vs. Rams over-under total: 53 points
  • Bills vs. Rams Moneyline: Bills -135, Rams +115
  • BUF: The bill covers four of the last five meetings of this rivalry.
  • LAR: Rams cover season opener in five straight games
  • Bills vs. Rams Picks: Pick Here

Featured game | | Los Angeles Rams vs. Buffalo Bills

Why bills can cover

The Bills are widely expected to have an even more explosive passing game this year, as a handful of young players who contributed last year are called upon to thrive in key roles. In the offseason, the team parted ways with reliable veteran slot receiver Cole Beasley and veteran Deep He Threatened Emmanuel Saunders. Both were club heavyweights. But Buffalo’s coaching staff and countless football his observers are excited about the potential of replacing Isaiah his Mackenzie and Gabriel his Davis.

Last season, when Beasley sat out Week 16 due to COVID-19 protocols, Mackenzie had 11 catches for 125 yards and a touchdown. The speedy Davis emerged as a big-play threat in the closing stages and secured a role in the starting rotation in one of his most memorable postseason performances for receivers. Central His Florida native, in the regular season he finished with 35 catches for 549 yards and six touchdowns, but his performance in the playoffs was impressive. Davis had eight catches on 10 targets for 201 yards and four touchdowns in Buffalo’s 42–36 loss to Kansas City in the divisional round.

Why the Rams Can Cover

Coach Sean McVay recently told the media that the team hopes the leading tandem of Kam Akers and Darrell Henderson is in perfect health heading into the season opener. Expected back Akers missed most of last year with a torn ACL, but returned ahead of schedule for the team’s postseason run. Added a catch.

Although effective when healthy, Henderson missed the final five games of the season due to repeated lower-body soft tissue injuries. He still managed 149 carries for 688 yards and 5 touchdowns, adding 176 receiving yards and 3 scoring. After watching both running backs perform a series of full practices, McVay told the media he was thrilled with what he saw. Took the rep and it was good, I expect everyone to be on deck,” McVay said.

How to make a Rams vs. Bills pick

White has analyzed this matchup and while we can see that he’s leaning toward point totals, he’s also discovered a key X-factor that jumps one entire side of the spread. He just shares on SportsLine what it is and which side he stands for.

So who will win the Bills vs. Rams in NFL Kickoff Game 2022, and which X-Factor will have the most impact on one side of the spread? Check and find out which side of the Bills vs. Rams spread you should jump on from -33 experts.